Sandbox Reserved 1502: Difference between revisions
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HIV-1 integrase is composed of three domains: the N-terminal (residues 1-49), the core domain (residues 50-212) and the C-terminal domain (residues 213-288). The core domain is responsible for the catalytic activity of the enzyme. It contains three acidic residues, the D,D-35-E motif which plays a key role in catalysis. The N-terminal domain includes the conserved HHCC motif, which binds zinc. The C-terminal domain is less well conserved. [http://www.jbc.org/content/276/26/23213/F2.expansion.html] | HIV-1 integrase is composed of three domains: the N-terminal (residues 1-49), the core domain (residues 50-212) and the C-terminal domain (residues 213-288). The core domain is responsible for the catalytic activity of the enzyme. It contains three acidic residues, the D,D-35-E motif which plays a key role in catalysis. The N-terminal domain includes the conserved HHCC motif, which binds zinc. The C-terminal domain is less well conserved. [http://www.jbc.org/content/276/26/23213/F2.expansion.html] | ||
'''Representation of the three domain of the HIV integrase'''' | |||
[[Image:Domain_HIV_Integrase.jpg]] | [[Image:Domain_HIV_Integrase.jpg]] | ||
'''HIV integrase sequence''' | |||
[[Image:HIV_Integrase_Sequence.jpg]] | |||
[[Image:HIV Integrase sequence.jpg]] | [[Image:HIV Integrase sequence.jpg]] | ||
====Structure and role of the core domain in the integration==== | |||
