Sandbox Reserved 1508: Difference between revisions
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
The protein 5C04 is classified as an oxidoreductase. We found it in the ''Mycobacterium tuberculosis'' organism, especially in the strain ATCC 25618/H37Rv. It can be expressed in ''Escherichia Coli'' bacteria. This is a pathogenic protein which is involved in the tuberculosis. Its pathogenicity is due to a specific mutation in the active site of peroxiredoxins. | The protein 5C04 is classified as an oxidoreductase. We found it in the ''Mycobacterium tuberculosis'' organism, especially in the strain ATCC 25618/H37Rv. It can be expressed in ''Escherichia Coli'' bacteria. This is a pathogenic protein which is involved in the tuberculosis. Its pathogenicity is due to a specific mutation in the active site of peroxiredoxins. | ||
<ref>DOI: 10.2210/pdb5C04/pdb</ref> | <ref>DOI: 10.2210/pdb5C04/pdb</ref> | ||
== Background == | == Background == | ||
In oxidative stress, the organism manage to do a reduction of peroxides. This reaction is catalyzed by the peroxiredoxins. From a structural point of view, a specific amino acid is involved in this reaction: its a nucleophilic cystein, called peroxidatic cystein. In order to understand the mechanism and the specificity of this reaction according to its specific chemical environment, researchers used the ''Mycobacterium tuberculosis'' alkyl hydroperoxide reductase E (MtAhpE) as model (Pedre et al, 2016). The mutational effects of key residues in its environment are located in the active site. These amino acids create an environment favorising the reaction with peroxides. | In oxidative stress, the organism manage to do a reduction of peroxides. This reaction is catalyzed by the peroxiredoxins. From a structural point of view, a specific amino acid is involved in this reaction: its a nucleophilic cystein, called peroxidatic cystein. In order to understand the mechanism and the specificity of this reaction according to its specific chemical environment, researchers used the ''Mycobacterium tuberculosis'' alkyl hydroperoxide reductase E (MtAhpE) as model (Pedre et al, 2016). The mutational effects of key residues in its environment are located in the active site. These amino acids create an environment favorising the reaction with peroxides. | ||
