Sandbox Reserved 1493: Difference between revisions
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{{Sandbox_Reserved_ESBS}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_ESBS}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
== | == Integrin αIIbβ3 (2VDL) == | ||
Integrin αIIbβ3 (or glycoprotein IIb/IIIa) is a complex present on the membrane of platelets that intervenes in the activation, adherence and aggregation of platelets during clotting. It is a cation-dependant heterodimeric transmembrane receptor containing a large extracellular headpiece and short intracellular tails. It is synthesized in megakaryocytes. | |||
Its particular shape and localisation on the membrane allows both ligand binding and transduction of the activation signal. It is the dominant integrin on platelets with 70,000 to 90,000 receptors expressed on each platelet in the resting state. | |||
The headpiece (2VDL) of integrin αIIbβ3 enables cation-facilitated ligand binding with multiple ligands (most known being fibrinogen, fibronectin, von Willebrand factors, thrombospondin and vitronectin). Binding affinity is dynamic and depends on the conformational status of the receptor. | |||
<StructureSection load='2vdl' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='2vdl' size='340' side='right' caption='Caption for this structure' scene=''> | ||
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
