Sandbox Reserved 1502: Difference between revisions

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== Interaction between the HIV integrase and LEDGF/p75 ==

LEDGF/p75, or Lens epithelium-derived growth factor, is a cellular cofactor of HIV integrase. It promotes the viral integration of the retrovirus by tethering the preintegration complex to the chromatin. Research on the ~~interaction between~~ LEDGF/p75 ~~and the~~ integrase [https://www.nature.com/articles/nchembio.370] shows that it ~~is possible to prevent contact between~~ the ~~two proteins~~. Thus, the viral DNA will not be inserted into the genome of the host cell.

LEDGF/p75, or Lens epithelium-derived growth factor, is a cellular cofactor of HIV integrase. It promotes the viral integration of the retrovirus by tethering the preintegration complex to the chromatin. Research on the LEDGF/p75-integrase interaction [https://www.nature.com/articles/nchembio.370] shows that it can be inhibited by using a molecule which will take the place of LEDGF/p75 on its binding site. Thus, the viral DNA will not be inserted into the genome of the host cell and the replication of HIV won't be possible.

====Use of antiviral to ~~slow down infection~~ ====

====Use of antiviral to inhibit the LEDGF/p75-integrase interaction ====

An antiviral refers to a molecule disrupting the replication cycle of one or more viruses, thus allowing to slow down but rarely to stop a viral infection. Antiviral targeting specific regions of the integrase are used to prevent the replication of HIV. For example, the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinoline-3-yl)acetic acid, interacts with <scene name='80/802676/Site_of_interaction/7'>the binding site of the LEDGF/p75 cofactor</scene>. This site is situated in the core domain. Once it is fixed into the core domain, the LEDGF/p75 will not be able to join and viral integration of the retrovirus will not be possible anymore.

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@@ Line 68: / Line 68: @@
 == Interaction between the HIV integrase and LEDGF/p75 ==
-LEDGF/p75, or Lens epithelium-derived growth factor, is a cellular cofactor of HIV integrase. It promotes the viral integration of the retrovirus by tethering the preintegration complex to the chromatin. Research on the interaction between LEDGF/p75 and the integrase [https://www.nature.com/articles/nchembio.370] shows that it is possible to prevent contact between the two proteins. Thus, the viral DNA will not be inserted into the genome of the host cell.
+LEDGF/p75, or Lens epithelium-derived growth factor, is a cellular cofactor of HIV integrase. It promotes the viral integration of the retrovirus by tethering the preintegration complex to the chromatin. Research on the LEDGF/p75-integrase interaction [https://www.nature.com/articles/nchembio.370] shows that it can be inhibited by using a molecule which will take the place of LEDGF/p75 on its binding site. Thus, the viral DNA will not be inserted into the genome of the host cell and the replication of HIV won't be possible.
-====Use of antiviral to slow down infection ====
+====Use of antiviral to inhibit the LEDGF/p75-integrase interaction ====
 An antiviral refers to a molecule disrupting the replication cycle of one or more viruses, thus allowing to slow down but rarely to stop a viral infection. Antiviral targeting specific regions of the integrase are used to prevent the replication of HIV. For example, the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinoline-3-yl)acetic acid, interacts with <scene name='80/802676/Site_of_interaction/7'>the binding site of the LEDGF/p75 cofactor</scene>. This site is situated in the core domain. Once it is fixed into the core domain, the LEDGF/p75 will not be able to join and viral integration of the retrovirus will not be possible anymore.