Sandbox Reserved 1508: Difference between revisions
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Peroxiredoxins are peroxidases which catalyze the reduction of peroxides (organic peroxide H2O2 or organic hydroperoxides). | Peroxiredoxins are peroxidases which catalyze the reduction of peroxides (organic peroxide H2O2 or organic hydroperoxides). | ||
== Biological function == | == Biological function == | ||
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According to researches on biosynthetic pathway in ''Mycobacterium tuberculosis'' (Burns et al, 2008), there are three pathways implicated cysteine in this disease: the sulfide dependent pathway, the cystathionine pathway and the CysO-thiocarboxylate pathway. For the CysO depending pathway, transcriptional profile analysis shown that cysM and cysO are upregulated under oxidative stress conditions. Moreover, the thiocarboxylate are much more resistant to oxidation than thiols. Thus, when the disease occurs, the environment becomes highly oxidizing due to the macrophages, leads to the cysteine biosynthesis. The CysO-thiocarboxylate evolves as an oxidation resistant form of sulfide, thiol is favored for the cysteine biosynthesis. | According to researches on biosynthetic pathway in ''Mycobacterium tuberculosis'' (Burns et al, 2008), there are three pathways implicated cysteine in this disease: the sulfide dependent pathway, the cystathionine pathway and the CysO-thiocarboxylate pathway. For the CysO depending pathway, transcriptional profile analysis shown that cysM and cysO are upregulated under oxidative stress conditions. Moreover, the thiocarboxylate are much more resistant to oxidation than thiols. Thus, when the disease occurs, the environment becomes highly oxidizing due to the macrophages, leads to the cysteine biosynthesis. The CysO-thiocarboxylate evolves as an oxidation resistant form of sulfide, thiol is favored for the cysteine biosynthesis. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
