Sandbox Reserved 1482: Difference between revisions
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Factor VIII is produced inside the liver (by the sinusoidal cells) and outside (by the endothelial cells) and acts in the intrinsic pathway of blood coagulation <ref name="wikipedia" /> <sup>[8]</sup>. It is actually the lack or the deficiency of the factor VIII (which is a plasma glycoprotein) that causes a bleeding disorder: hemophilia A <ref name="Ngo" /> <sup>[9]</sup>. | Factor VIII is produced inside the liver (by the sinusoidal cells) and outside (by the endothelial cells) and acts in the intrinsic pathway of blood coagulation <ref name="wikipedia" /> <sup>[8]</sup>. It is actually the lack or the deficiency of the factor VIII (which is a plasma glycoprotein) that causes a bleeding disorder: hemophilia A <ref name="Ngo" /> <sup>[9]</sup>. | ||
Factor VIII is much studied in order to find a cure for hemophilia A (also written as HEMA), for instance by designing mimicking factors <sup>[12]</sup>. | Factor VIII is much studied in order to find a cure for hemophilia A (also written as HEMA), for instance by designing mimicking factors <ref>Ragni, M. V. (2018). Mimicking Factor VIII to Manage the Factor VIII–Deficient State. The New England journal of medicine, 379(9), 880-882.</ref><sup>[12]</sup>. | ||
