6akl: Difference between revisions
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==Crystal structure of Striatin3 in complex with SIKE1 Coiled-coil domain== | |||
<StructureSection load='6akl' size='340' side='right' caption='[[6akl]], [[Resolution|resolution]] 1.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6akl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AKL FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6akl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6akl OCA], [http://pdbe.org/6akl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6akl RCSB], [http://www.ebi.ac.uk/pdbsum/6akl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6akl ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/SIKE1_HUMAN SIKE1_HUMAN]] Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.<ref>PMID:16281057</ref> [[http://www.uniprot.org/uniprot/STRN3_HUMAN STRN3_HUMAN]] Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chen, M]] | |||
[[Category: Zhou, L]] | |||
[[Category: Zhou, Z C]] | |||
[[Category: Coiled-coil domain]] | |||
[[Category: Heterotrimer]] | |||
[[Category: Protein binding]] | |||
Revision as of 12:00, 16 January 2019
Crystal structure of Striatin3 in complex with SIKE1 Coiled-coil domain
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