6akm: Difference between revisions
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==Crystal structure of SLMAP-SIKE1 complex== | |||
<StructureSection load='6akm' size='340' side='right' caption='[[6akm]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6akm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AKM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6akm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6akm OCA], [http://pdbe.org/6akm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6akm RCSB], [http://www.ebi.ac.uk/pdbsum/6akm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6akm ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/SLMAP_HUMAN SLMAP_HUMAN]] Brugada syndrome. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SIKE1_HUMAN SIKE1_HUMAN]] Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.<ref>PMID:16281057</ref> [[http://www.uniprot.org/uniprot/SLMAP_HUMAN SLMAP_HUMAN]] May play a role during myoblast fusion. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chen, M]] | |||
[[Category: Ma, J]] | |||
[[Category: Zhou, Z C]] | |||
[[Category: Coiled-coil domain]] | |||
[[Category: Heterotetramer]] | |||
[[Category: Protein binding]] | |||
Revision as of 12:00, 16 January 2019
Crystal structure of SLMAP-SIKE1 complex
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