6c6n: Difference between revisions
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==Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and Cmpd-4"== | |||
<StructureSection load='6c6n' size='340' side='right' caption='[[6c6n]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6c6n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C6N FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=EKV:N-[(3-{[dimethyl(2-methylphenyl)silyl]methoxy}phenyl)methyl]-N-ethyl-6-methoxy-6-methylhepta-2,4-diyn-1-amine'>EKV</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6c6p|6c6p]], [[6c6r|6c6r]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_monooxygenase Squalene monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.17 1.14.14.17] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6n OCA], [http://pdbe.org/6c6n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c6n RCSB], [http://www.ebi.ac.uk/pdbsum/6c6n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6n ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ERG1_HUMAN ERG1_HUMAN]] Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Squalene monooxygenase]] | |||
[[Category: Jin, L]] | |||
[[Category: Padyana, A K]] | |||
[[Category: 3-epoxidase]] | |||
[[Category: Cholesterol synthesis pathway]] | |||
[[Category: Erg1]] | |||
[[Category: Fad-dependent monooxygenase]] | |||
[[Category: Flavoprotein]] | |||
[[Category: Flavoprotein-inhibitor complex]] | |||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | |||
[[Category: Sqle]] | |||
[[Category: Squalene hydroxylase]] | |||
[[Category: Squalene-2]] | |||
