6gc5: Difference between revisions
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==Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM== | |||
<StructureSection load='6gc5' size='340' side='right' caption='[[6gc5]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6gc5]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GC5 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gc5 OCA], [http://pdbe.org/6gc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gc5 RCSB], [http://www.ebi.ac.uk/pdbsum/6gc5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gc5 ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ELAV1_HUMAN ELAV1_HUMAN]] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.<ref>PMID:19029303</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Allain, F H]] | |||
[[Category: Ripin, N]] | |||
[[Category: Dimer]] | |||
[[Category: Elav]] | |||
[[Category: Hur]] | |||
[[Category: Rna binding protein]] | |||
[[Category: Rrm]] | |||
[[Category: Rrm3]] | |||
Revision as of 08:24, 30 January 2019
Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM
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