Major histocompatibility complex

spinqualitylabelsall models Human MHC class I antigen (cyan) withβ 2-microglobulin (green) and peptide from Hepatitis virus (deeppink) 3ox8 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Major Histocompatibility Complex (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response. MHC class I (Major Histocompatibility Complex Class I) are found in all nucleated cells. These cell surface proteins display peptides from cellular intrinsic proteins. For more details see Effect of HCMV on Major Histocompatibility Complex Class I MR1 Binds Vitamin Metabolites. MHC class II are found in professional antigen-presenting cells like macrophages. These cell surface proteins display peptides from cellular extrinsic proteins. Structural highlights Human MHC class I antigen with β 2-microglobulin and peptide from Hepatitis virus. The peptide derived from Hepatitis virus binds MHC in a peptide-recognition groove and makes various interactions with side chains and with water molecules. Water molecules shown as red spheres.

3D structures of MHC

Updated on 05-February-2019

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• MHC I
• MHC I binary complex
  • Major Histocompatibility Complex Class I - mMHC I + β-2-microglobulin – mouse
    
  • Effect of HCMV on Major Histocompatibility Complex Class I, MR1 Binds Vitamin Metabolites, 1hla - hMHC I + β-2-microglobulin – human
    
  • 3p73, 3p77 - cMHC I + β-2-microglobulin – chicken
• MHC I ternary complex
  • 4d0b, 3bew, 2yez, 5ad0, 4d0c, 3bev, 4cvx – cMHC I α + β-2-microglobulin + peptide
    
  • 3kpn, 3kpo – hMHC I B + β-2-microglobulin + peptide
    
  • 3bev, 1kpr, 1k5n, 3nfn, 3mr9, 3mrb, 3mrc, 3mrd, 3mre, 3mrf, 3mrg, 3mrh, 3mri, 3mrj, 3mrk, 3mrl, 3mrm, 3mrn, 3mro, 3mrp, 3mrq, 3mrr, 3ox8, 3oxr, 3oxs, 2xpg, 3pwj, 3pwl, 3pwn, 3pwp, 2x70, 3o3a, 3o3b, 3o3d, 3o3e, 3lv3, 3ln4, 3ln5, 3myj, 3i6l, 3lkn, 3lko, 3lkp, 3lkq, 3lkr, 3lks, 3hpj, 3i6g, 3i6k, 3mgo, 3mgt, 3l3d, 3l3g, 3l3i, 3l3j, 3l3k, 2x4n, 2x4o, 2x4p, 2x4q, 2x4r, 2x4s, 2x4t, 2x4u, 3lka, 3h7b, 3kpl, 3kpm, 3kpn, 3kpo, 3kpp, 3kpq, 3kpr, 3kps, 3giv, 3hcv, 3d18, 3dtx, 3czf, 3fqn, 3fqr, 3fqt, 3fqu, 3fqw, 3fqx, 3d25, 3bvn, 3dx6, 3dx7, 3dx8, 3dxa, 3bo8, 3bp4, 3bp7, 3bgm, 3bh8, 3bh9, 3bhb, 3b3i, 3b6s, 2rfx, 3bze, 3bzf, 3bw9, 3bwa, 3c9n, 2v2w, 2v2x, 2gt9, 2gtw, 2gtz, 2guo, 2nw3, 2fyy, 2fz3, 2hn7, 2cik, 2git, 2hjk, 2hjl, 2h6p, 2d31, 2c7u, 2bck, 2a83, 2axf, 2axg, 2bvo, 2bvp, 2bvq, 1s8d, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1s7q, 1zsd, 2bsr, 2bss, 2bst, 1zhk, 1zhl, 1tvb, 1tvh, 1xr8, 1xr9, 1w0v, 1w0w, 1xh3, 1uxs, 1uxw, 1s9w, 1s9x, 1s9y, 1q94, 1qvo, 1n2r, 1ogt, 1qew, 1jge, 1k5n, 1i7r, 1i7t, 1i7u, 1jf1, 1jht, 1i4f, 1e27, 1e28, 1i1y, 1i1f, 1qqd, 1mhe, 1b0g, 1a9b, 1a9e, 1a1m, 1a1n, 1a1o, 1tmc, 2clr, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hsb, 1hsa, 3to2, 2vab - hMHC I α + β-2-microglobulin + peptide
    
  • 1ktl, 3kww, 3h9h, 3ixa, 3gso, 3gsq, 3gsr, 3gsu, 3gsv, 3gsw, 3gsx, 3ft2, 3ft3, 3ft4, 2av1, 2av7, 1cg9, 1m05, 1m6o, 1kpr, 1ktl - hMHC I α (mutant) + β-2-microglobulin + peptide
    
  • 1syv, 1n2r, 1syv - hMHC I + β-2-microglobulin + hMHC II peptide
    
  • 1kjv, 1kjm, 1ed3 – MHC I α + β-2-microglobulin + peptide - rat
    
  • 2oi9 - mMHC I α + T cell receptor + peptide
    
  • 1kbg, 3l3h, 3ftg, 3e6f, 3ecb, 3ch1, 3cch, 3cc5, 3cpl, 2zsv, 2zsw, 2zok, 2zol, 3buy, 2ve6, 2e7l, 2fo4, 2cii, 2fwo, 2f74, 1zt1, 1zt7, 1vgk, 1yn6, 1yn7, 1zhb, 1wbx, 1wby, 1wbz, 1rjy, 1rjz, 1rk0, 1rk1, 1t0m, 1t0n, 1s7q, 1s7r, 1s7s, 1s7t, 1s7u, 1s7v, 1s7w, 1s7x, 1lk2, 1kpu, 1kpv, 1n3n, 1nan, 1n59, 1n5a, 1ffn, 1ffo, 1ffp, 1g7p, 1g7q, 1lek, 1leg, 1inq, 1juf, 1k8d, 1jpf, 1jpg, 1fg2, 1qlf, 1bz9, 1kbg, 1hoc, 2mha, 1vad, 1vac, 3roo, 3quk, 3qul, 3rol, 3tbs, 3tbt, 3tbv, 3tbw, 4nsk, 3tby - mMHC I + β-2-microglobulin + peptide
    
  • 2qri - mMHC I/β-2-microglobulin/peptide
    
  • 2qrs, 2qrt - mMHC I (mutant)/β-2-microglobulin/peptide
    
  • 1mhc, 2clv, 2clz, 1fzj, 1fzk, 1fzm, 1fzo, 1ddh - mMHC I (mutant) + β-2-microglobulin + peptide
    
  • 3e2h, 3e3q, 2e7l - mMHC I α (mutant) + T cell receptor + peptide
    
  • 1nez - mMHC I + β-2-microglobulin + CD8 α chain
    
  • 3rwc, 3rwd, 3rwe, 3rwf, 3rwg, 3rwh, 3rwi, 3rwj, 4zfz - MHC I + β-2-microglobulin + peptide – Rhesus macaque
    
  • 3qq3, 3qq4 - MHC I + β-2-microglobulin + peptide - pig
• MHC I quaternary complex
  • 3qdg, 3qdj, 3qdm, 3qeq, 3mv7, 3mv9, 3h9s, 3gsn, 3d39, 3d3v, 3ffc, 2vlj, 2vlk, 2vll, 2vlr, 2j8u, 2p5e, 2p5w, 2pye, 2gj6, 2f54, 2esv, 2bnq, 2bnr, 1lp9, 1oga, 1mi5, 1qrn - hMHC I α + T cell receptor + β-2-microglobulin + peptide
    
  • 3kxf, 3mv8, 2jcc, 2uwe - hMHC I α (mutant) + T cell receptor + β-2-microglobulin + peptide
    
  • 2f53 - hMHC I α + T cell receptor + β-2-microglobulin (mutant) + peptide
    
  • 1p7q, 1im9 - hMHC I α + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide
    
  • 2dyp - hMHC I α (mutant) + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide
    
  • 3qzw, 3dmm, 1bqh, 1akj - hMHC I α + β-2-microglobulin + CD8 α + peptide
    
  • 1im3 - hMHC I α + β-2-microglobulin + cytomegalovirus protein US2 + peptide
    
  • 3cii, 3cdg - hMHC I α + β-2-microglobulin + CD94 ectodomain + NKG2A/NKG2B integral membrane protein + peptide
    
  • 3hae, 3gjf, 3cvh, 1w72 - hMHC I α + β-2-microglobulin + antibody + peptide
    
  • 1g6r, 2ckb, 3pqy, 2z31, 1nam, 1mwa, 1g6r, 2ckb - mMHC I + T cell receptor + β-2-microglobulin + peptide
    
  • 2oi9 - mMHC I (mutant) + T cell receptor + β-2-microglobulin + peptide
    
  • 1p1z, 1p4l, 1qo3 - mMHC I + β-2-microglobulin + natural killer cell receptor LY49C + peptide
    
  • 3c8k - mMHC I (mutant) + β-2-microglobulin + natural killer cell receptor LY49C + peptide
    
• MHC II
  • 3lqz, 2bc4, 1hdm - hMHC II α+β
    
  • 3pdo, 3pgc, 3pgd, 1a6a - hMHC II α+β+γ
    
  • 3cup, 2p24, 1lnu, 1fng - mMHC II α+β
    
  • 1fne - mMHC II α+β (mutant)
    
  • 3lqz - hMHC II α+β DP2
• MHC II binary complex
  • 1h15 - hMHC II α+β + DNA polymerase peptide
    
  • 1fv1 - hMHC II α+β + myelin basic protein
    
  • 3o6f, 2wbj - hMHC II α+β + T cell receptor
    
  • 3l6f, 3c5j, 2q6w, 2fse, 1t5w, 1s9v, 1uvq, 1h15, 1fv1 – hMHC II α+β + peptide
    
  • 1dlh - hMHC II α+β + enterotoxin
    
  • 3c5z, 3c60, 3c6l - mMHC II α+β + T cell receptor
    
  • 1r5v, 1k2d, 1muj, 1kt2, 1ktd, 1f3j, 1es0, 1iak, 1iea, 1ieb, 1f3j - mMHC II α+β + peptide
    
  • 1aqd - mMHC II α+β + MHC I peptide
    
  • 1r5w, 1i3r - mMHC II α+β (mutant) + peptide
    
• MHC II ternary complex
  • 1zgl, 1j8h, 1fyt - hMHC II α+β + T cell receptor + peptide
    
  • 2iam, 2ian, 1ymm, 4gg6 – hMHC II α+β + T cell receptor (mutant) + peptide
    
  • 2ipk, 2g9h, 1pyw, 1jwm, 1jws, 1jwu, 1klg, 1klu, 1hxy, 1d5m, 1d5x, 1d5z, 1d6e, 2seb, 1seb - hMHC II α+β + enterotoxin + peptide
    
  • 1sje, 1sjh, 1t5x, 1lo5 - hMHC II α+β + enterotoxin (mutant) + peptide
    
  • 1r5i - hMHC II α+β + mycoplasma arthritidis mitogen+ peptide
    
  • 2oje - mMHC II α+β + mycoplasma arthritidis mitogen+ peptide
    
  • 2xn9, 3qib, 1zgl, 3qiu, 3qiw, 3mbe - mMHC I + T cell receptor + peptide
    
  • 2pxy, 1u3h - mMHC II α+β + T cell receptor (mutant) + peptide
    
  • 1jl4 - mMHC II α+β + CD4 + peptide
    
• MHC II quaternary complex
  • 2icw - mMHC II α+β + T cell receptor + mycoplasma arthritidis mitogen + hemagglutinin peptide
    
  • 4c56 - hMHC II + + T cell receptor + enterotoxin + hemagglutinin peptide
    

Proteopedia Page Contributors and Editors (what is this?)

Tihitina Y Aytenfisu, Michal Harel, Eric Martz, Alexander Berchansky, Sandra B. Gabelli, Joel L. Sussman