6nm4: Difference between revisions

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'''Unreleased structure'''


The entry 6nm4 is ON HOLD
==Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor==
 
<StructureSection load='6nm4' size='340' side='right' caption='[[6nm4]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
Authors: Ivanochko, D., Halabelian, L., Fischer, C., Sanders, J.M., Kattar, S.D., Brown, P.J., Edwards, A.M., Bountra, C., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6nm4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NM4 FirstGlance]. <br>
Description: Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KS7:4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane'>KS7</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
[[Category: Arrowsmith, C.H]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nm4 OCA], [http://pdbe.org/6nm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nm4 RCSB], [http://www.ebi.ac.uk/pdbsum/6nm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nm4 ProSAT]</span></td></tr>
[[Category: Brown, P.J]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).
__TOC__
</StructureSection>
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Brown, P J]]
[[Category: Edwards, A M]]
[[Category: Fischer, C]]
[[Category: Fischer, C]]
[[Category: Halabelian, L]]
[[Category: Halabelian, L]]
[[Category: Ivanochko, D]]
[[Category: Ivanochko, D]]
[[Category: Edwards, A.M]]
[[Category: Kattar, S D]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Structural genomic]]
[[Category: Kattar, S.D]]
[[Category: Sanders, J M]]
[[Category: Sanders, J.M]]
[[Category: Gene regulation-inhibitor complex]]
[[Category: Bountra, C]]
[[Category: Inhibitor]]
[[Category: Lysine methyltransferase]]
[[Category: Pr set domain]]
[[Category: Sgc]]
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