Choline kinase

spinqualitylabelsall models Structure of human choline kinaseα2 complex with phosphocholine (PDB code 2ckq). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Choline kinase (CK) catalyzes the conversion of choline and ATP to phosphocholine and ADP. CK is part of phosphatidylcholine biosynthesis. Disease Overexpression of CK α1 was found in various types of cancer cells. This can aid in promoting cancer cells survival and growth. CK α1 is used as cancer biomarker and anticancer drug target. Structural highlights The choline binds to CK in a deep hydrophobic groove (PDB code 2ckq; Hydrophobic, Polar) and the ADP binds in a cleft (PDB code 2ckp).

3D structures of choline kinase

Updated on 13-February-2019

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• Choline kinase
  • 2ckq – hCK α – human
    
  • 2ckp – hCK α2
    
  • 2ig7 – hCK β
    
  • 1nw1 – CK – Caenorhabditis elegans
    
  • 3c5i – CK – Plasmodium knowlesi
    
  • 3fi8 – CK – Plasmodium falciparum
    
  • 3mes – CK – Cryptosporidium pavrum
    
  • 4r77 – SpCK – Streptococcus pneumoniae
    
• Choline kinase complexes
  • 2ckp – hCK α2 + ADP
    
  • 2ckq – hCK α2 + phosphocholine
    
  • 3zm9, 4da5, 4br3, 5afv, 5eqe, 5eqp, 5eqy, 5ftg, 5fut – hCK α + inhibitor
    
  • 3f2r – hCK α + hemicholinium-3
    
  • 3g15 – hCK α + hemicholinium-3 + ADP
    
  • 3lq3, 3feg – hCK β + hemicholinium-3 + ADP
    
  • 4cg8, 4cg9, 4cga – hCK α1 + bispyridinium derivative
    
  • 4r78 – SpCK + AMP
    
  • 4r7b – SpCK + choline
    

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Michal Harel, Alexander Berchansky