Retroviral Integrase: Difference between revisions
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Three-dimensional structures for certain host-cell proteins critical to understanding the mechanism of HIV infection and virulence have emerged from X-ray crystallographic analyses. HIV protease and integrase structures are among the highest ranked structures that have contributed to saving many lives and added to the quality of life of many HIV-afflicted individuals. It is implemented in [[Structure-based drug design|structure-based drug design]] to develop [http://en.wikipedia.org/wiki/Protease_inhibitors protease inhibitors] and [http://en.wikipedia.org/wiki/Integrase_inhibitors integrase inhibitors], and is used as a significant component of ''highly active anti-retroviral therapy'' ([http://en.wikipedia.org/wiki/Haart HAART]). | Three-dimensional structures for certain host-cell proteins critical to understanding the mechanism of HIV infection and virulence have emerged from X-ray crystallographic analyses. HIV protease and integrase structures are among the highest ranked structures that have contributed to saving many lives and added to the quality of life of many HIV-afflicted individuals. It is implemented in [[Structure-based drug design|structure-based drug design]] to develop [http://en.wikipedia.org/wiki/Protease_inhibitors protease inhibitors] and [http://en.wikipedia.org/wiki/Integrase_inhibitors integrase inhibitors], and is used as a significant component of ''highly active anti-retroviral therapy'' ([http://en.wikipedia.org/wiki/Haart HAART]). | ||
While existing antiretroviral agents improve the quality of life as well as extending the life of many patients, it fails to eradicate the disease. Studies in integrase inhibitors show that combination with other antiretroviral drugs diminish viral adaptations, and may have the potential to be used for ''salvage therapy'' for patients who have acquired resistance to other drugs. For more, please see [[User:Eric_Martz/Molecular_Playground/HIVDrug|AIDS Before Protease Inhibitors & HIV Protease Inhibitors: A Breakthrough]]. | While existing antiretroviral agents improve the quality of life as well as extending the life of many patients, it fails to eradicate the disease. Studies in integrase inhibitors show that combination with other antiretroviral drugs diminish viral adaptations, and may have the potential to be used for ''salvage therapy'' for patients who have acquired resistance to other drugs. For more, please see<br /> | ||
*[[User:Eric_Martz/Molecular_Playground/HIVDrug|AIDS Before Protease Inhibitors & HIV Protease Inhibitors: A Breakthrough]]<br /> | |||
*[[Treatments:Retroviral Integrase Inhibitor Pharmacokinetics References]]. | |||
==PFV Intasome Crystallization== | ==PFV Intasome Crystallization== | ||
