Cutinase

spinqualitylabelsall models Structure of cutinase (PDB entry 4oyl) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Cutinase (CUT) catalyzes the conversion of cutin to cutin monomers. Cutin is a main component of the plant cuticle. Polymeric cutin which is composed of hydroxyl and hydroxyepoxy fatty acids is found in the outer layer of plants. CUT is found in fungi and bacteria. CUT degrades the cutin enabling pathogens’ penetration into plant cells. CUT is inhibited by organophosphates like E600 (diethyl-p-nitrophenyl phosphate) and organophosphonates. Relevance Inhibition of CUT can prevent fungal plant infection. Structural highlights Upon CUT inhibition by organophosphates the catalytic triad of Ser-His-Asp exhibits esterification of Ser and ethylation of His.

3D Structures of cutinase

Updated on 18-February-2019

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• Cutinase
  • 1cus, 2cut, 1oxm, 1cex, 1agy, 3qpa – NhCUT – Nectria haematococca
    
  • 1ffa, 1ffb, 1ffc, 1ffd, 1ffe, 1cua, 1cub, 1cuc, 1cud, 1cue, 1cuf, 1cug, 1cuh, 1cui, 1cuj, 1cuu, 1cuv, 1cuw, 1cux, 1cuy, 1cuz, 1xza, 1xzb, 1xzc, 1xzd, 1xze, 1xzf, 1xzg, 1xzh, 1xzi, 1xzj – NhCUT (mutant)
    
  • 3dcn – GcCUT – Glomerella cingulata
    
  • 3gbs – CUT – Aspergillus oryzae
    
  • 3esc – CUT – Fusarium solani
    
  • 4cg1, 4cg2, 4cg3 – CUT – Thermobifida fusca
    
  • 4oyy – HiCUT – Humicola insolens
    
  • 4wfi, 4wfj, 4wfk – CUT (mutant) – Sacchromonospora viridis
    
  • 5ajh – CUT – Fusarium oxysporum
    
  • 4psc, 4psd – TrCUT – Trichoderma reesei
    
  • 5lui – TcCUT 1 – Thermobifida cellulosilytica
    
  • 5luj – TcCUT 2
    
  • 5luk, 5lul – TcCUT 2 (mutant)
    
  • 5x88 – CUT – Malbanchea cinnamonea
    
• Cutinase complex with inhibitor
  • 1xzl – NhCUT + hexylphosphonate ethyl ester
    
  • 1xzk – NhCUT + di-isopropyl phosphate
    
  • 1xzm – NhCUT + undecyl chloro phosphonate ester
    
  • 3dd5 – GcCUT + E600
    
  • 3dea – GcCUT + PETFP
    
  • 3ef3, 3esa, 3esb, 3eac, 3esd – NhCUT + Pt inhibitor
    
  • 3qpc – NhCUT + paraoxon
    
  • 3qpd – NhCUT + phosphoserine
    
  • 4oyl – HiCUT + ethyl phosphate
    
  • 4pse – TrCUT + phosphonate derivative
    

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Michal Harel, Alexander Berchansky