Dynamin

spinqualitylabelsall models Human dynamin 1 GTPase+GTPase effector domains complex with GDP and ethylene glycol (PDB code 5d3q) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Dynamin (DNM) is a GTPase which mediates endocytosis in membrane scission and organelle division. Dynamin 1-like mediates outer mitochondrial membrane fission. DNM is a multidomain GTPase. Mammalian genomes contain 3 DNM genes which show ca. 80% homology. DNM 1 is localized to neurons, DNM 2 is expressed ubiquitously and DNM 3 is found predominantly in the brain. The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and proline- and arginine-rich (PRD) domains. Disease Mutations in DNM-2 cause centronuclear myopathy. Structural highlights The GTPase domain of DNM 1 contains 5 nucleotide binding motifs all of which interact with the bound GDP. Motif #1 GGQSAGKS residues 38-45; motif #2 is residue T65; Motif #3 DLPG residues 136-139; Motif #4 TKLD residues 205-208; Motif #5 NRSQKDIDGKK reidues 236-246. Dynamin 3D structures See Dynamin 3D structures

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