6ett: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6ett is ~~ON HOLD until Paper Publication~~

==Crystal structure of KDM4D with tetrazole compound 4==

~~Authors~~: ~~Malecki~~, P.H., ~~Link~~, A., ~~Weiss~~, M.S., ~~Heinemann~~, U.

== Structural highlights ==

<table><tr><td colspan='2'>[[6ett]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ETT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ETT FirstGlance]. <br>

~~Description: Crystal structure of KDM4D with tetrazolylhydrazide ligand NR016~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BXH:ethyl+2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanoate'>BXH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ett FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ett OCA], [http://pdbe.org/6ett PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ett RCSB], [http://www.ebi.ac.uk/pdbsum/6ett PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ett ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Heinemann, U]]

[[Category: Link, A]]

[[Category: ~~Heinemann~~, U]]

[[Category: Malecki, P H]]

[[Category: Weiss, M.S]]

[[Category: Weiss, M S]]

[[Category: ~~Malecki, P.H~~]]

[[Category: Cancer]]

[[Category: Epigenetic]]

[[Category: Gene regulation]]

[[Category: Inhibitor design]]

[[Category: Kdm4d]]

[[Category: Ligand binding]]

[[Category: Tetrazole]]

[[Category: Tetrazolylhydrazide]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ett is ON HOLD  until Paper Publication
+==Crystal structure of KDM4D with tetrazole compound 4==
+<StructureSection load='6ett' size='340' side='right' caption='[[6ett]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
-Authors: Malecki, P.H., Link, A., Weiss, M.S., Heinemann, U.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ett]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ETT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ETT FirstGlance]. <br>
-Description: Crystal structure of KDM4D with tetrazolylhydrazide ligand NR016
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BXH:ethyl+2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanoate'>BXH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ett FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ett OCA], [http://pdbe.org/6ett PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ett RCSB], [http://www.ebi.ac.uk/pdbsum/6ett PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ett ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Heinemann, U]]
 [[Category: Link, A]]
-[[Category: Heinemann, U]]
+[[Category: Malecki, P H]]
-[[Category: Weiss, M.S]]
+[[Category: Weiss, M S]]
-[[Category: Malecki, P.H]]
+[[Category: Cancer]]
+[[Category: Epigenetic]]
+[[Category: Gene regulation]]
+[[Category: Inhibitor design]]
+[[Category: Kdm4d]]
+[[Category: Ligand binding]]
+[[Category: Tetrazole]]
+[[Category: Tetrazolylhydrazide]]