6hpv: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6hpv is ~~ON HOLD~~ ~~until Paper~~ Publication

==Crystal structure of mouse fetuin-B==

== Structural highlights ==

<table><tr><td colspan='2'>[[6hpv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HPV FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpv OCA], [http://pdbe.org/6hpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hpv RCSB], [http://www.ebi.ac.uk/pdbsum/6hpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpv ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/FETUB_MOUSE FETUB_MOUSE]] Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.<ref>PMID:23562279</ref>

== Publication Abstract from PubMed ==

A set of orthologous plasma proteins found in human, sheep, pig, cow and rodents, now collectively designated fetuin-A, constitutes the fetuin family. Fetuin-A has been identified as a major protein during fetal life and is also involved in important functions such as inhibition of the insulin receptor tyrosine kinase activity, protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. Furthermore, fetuin-A is a key partner in the recovery phase of an acute inflammatory response. We now describe a second protein of the fetuin family, called fetuin-B, which is found at least in human and rodents. On grounds of domain homology, overall conservation of cysteine residues and chromosomal assignments of the corresponding genes in these species, fetuin-B is unambiguously a paralogue of fetuin-A. Yet, fetuin-A and fetuin-B exhibit significant differences at the amino acid sequence level, notably including variations with respect to the archetypal fetuin-specific signature. Differences and similarities in terms of gene regulation were also observed. Indeed, studies performed during development in rat and mouse showed for the first time high expression of a member of the fetuin family in adulthood, as shown with the fetuin-B mRNA in rat. However, like its fetuin-A counterpart, the fetuin-B mRNA level is down-regulated during the acute phase of experimentally induced inflammation in rat.

~~Authors~~:

Fetuin-B, a second member of the fetuin family in mammals.,Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, Salier JP Biochem J. 2000 Sep 1;350 Pt 2:589-97. PMID:10947975<ref>PMID:10947975</ref>

~~Description~~:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased Structures~~]]

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Dietzel, E]]

[[Category: Fahrenkamp, D]]

[[Category: Jovine, L]]

[[Category: Sanctis, D de]]

[[Category: Cystatin domain]]

[[Category: Egg coat]]

[[Category: Fertilization]]

[[Category: Glycoprotein]]

[[Category: Hardening]]

[[Category: Hydrolase inhibitor]]

[[Category: Liver-secreted protein]]

[[Category: Metalloprotease inhibitor]]

[[Category: Ovastacin]]

[[Category: Zona pellucida]]

[[Category: Zp2]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6hpv is ON HOLD  until Paper Publication
+==Crystal structure of mouse fetuin-B==
+<StructureSection load='6hpv' size='340' side='right' caption='[[6hpv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6hpv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HPV FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpv OCA], [http://pdbe.org/6hpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hpv RCSB], [http://www.ebi.ac.uk/pdbsum/6hpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FETUB_MOUSE FETUB_MOUSE]] Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.<ref>PMID:23562279</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A set of orthologous plasma proteins found in human, sheep, pig, cow and rodents, now collectively designated fetuin-A, constitutes the fetuin family. Fetuin-A has been identified as a major protein during fetal life and is also involved in important functions such as inhibition of the insulin receptor tyrosine kinase activity, protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. Furthermore, fetuin-A is a key partner in the recovery phase of an acute inflammatory response. We now describe a second protein of the fetuin family, called fetuin-B, which is found at least in human and rodents. On grounds of domain homology, overall conservation of cysteine residues and chromosomal assignments of the corresponding genes in these species, fetuin-B is unambiguously a paralogue of fetuin-A. Yet, fetuin-A and fetuin-B exhibit significant differences at the amino acid sequence level, notably including variations with respect to the archetypal fetuin-specific signature. Differences and similarities in terms of gene regulation were also observed. Indeed, studies performed during development in rat and mouse showed for the first time high expression of a member of the fetuin family in adulthood, as shown with the fetuin-B mRNA in rat. However, like its fetuin-A counterpart, the fetuin-B mRNA level is down-regulated during the acute phase of experimentally induced inflammation in rat.
-Authors:
+Fetuin-B, a second member of the fetuin family in mammals.,Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, Salier JP Biochem J. 2000 Sep 1;350 Pt 2:589-97. PMID:10947975<ref>PMID:10947975</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6hpv" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Dietzel, E]]
+[[Category: Fahrenkamp, D]]
+[[Category: Jovine, L]]
+[[Category: Sanctis, D de]]
+[[Category: Cystatin domain]]
+[[Category: Egg coat]]
+[[Category: Fertilization]]
+[[Category: Glycoprotein]]
+[[Category: Hardening]]
+[[Category: Hydrolase inhibitor]]
+[[Category: Liver-secreted protein]]
+[[Category: Metalloprotease inhibitor]]
+[[Category: Ovastacin]]
+[[Category: Zona pellucida]]
+[[Category: Zp2]]