Sandbox Reserved 1482: Difference between revisions
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Hemophilia A (HEMA), is four times as common as hemophilia B. | Hemophilia A (HEMA), is four times as common as hemophilia B. | ||
It is caused by a deficiency of factor VIII. <ref name="Srivastava">Srivastava A, Brewer AK, Mauser‐Bunschoten EP, Key NS, Kitchen S, Llinas A, Ludlam CA, Mahlangu JN, Mulder K, Poon MC & Street A. Guidelines for the management of hemophilia. Haemophilia. 2013 Jan; 19(1): e1-e47. PMID: 22776238 doi: 10.1111/j.1365-2516.2012.02909.x</ref> | It is caused by a deficiency of factor VIII. <ref name="Srivastava">Srivastava A, Brewer AK, Mauser‐Bunschoten EP, Key NS, Kitchen S, Llinas A, Ludlam CA, Mahlangu JN, Mulder K, Poon MC & Street A. Guidelines for the management of hemophilia. Haemophilia. 2013 Jan; 19(1): e1-e47. PMID: 22776238 doi: 10.1111/j.1365-2516.2012.02909.x</ref> | ||
This deficiency in factor VIII clotting activity results in prolonged | This deficiency in factor VIII clotting activity results in prolonged delayed or recurrent bleeding prior to complete wound healing <ref name="Konkle">Konkle BA, Huston H & Fletcher SH. Hemophilia A, Synonym: Factor VIII Deficiency. Gene Rewiews. 2017 Jun. PMID: 20301578</ref>. | ||
Although hemophilia A is usually an inherited disease and therefore runs in families <ref name="Srivastava" />, about one-third of people with the disease are caused by a spontaneous mutation <ref name="Srivastava" /> such as misense or nonsense mutations, gene deletions or inversions <ref name="Ngo" />. | Although hemophilia A is usually an inherited disease and therefore runs in families <ref name="Srivastava" />, about one-third of people with the disease are caused by a spontaneous mutation <ref name="Srivastava" /> such as misense or nonsense mutations, gene deletions or inversions <ref name="Ngo" />. | ||
