Sandbox Reserved 1482: Difference between revisions
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== Function == | == Function == | ||
====Factor VIII plays a central role in blood coagulation==== | ====Factor VIII plays a central role in blood coagulation==== | ||
The Factor VIII circulates in the bloodstream in its inactive form, bound to another molecule called [[Von Willebrand Factor]], until an injury that damages blood vessels occurs. In plasma, factor VIII exists predominantly in a complex with the Von Willebrand factor, because this latter plays a role of stabilization. By contrast, in its free state, factor VIII is rapidly cleaved by [[Serine Proteases]] <ref name="wikipedia" /><ref name="El" />. | The Factor VIII circulates in the bloodstream in its inactive form, bound to another molecule called [[Von Willebrand Factor]], until an injury that damages blood vessels occurs. In plasma, factor VIII exists predominantly in a complex with the Von Willebrand factor, because this latter plays a role of stabilization. By contrast, in its free state, factor VIII is rapidly cleaved by [[Serine Proteases]] <ref name="wikipedia" /><ref name="El" />. | ||
====The coagulation process==== | ====The coagulation process==== | ||
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====Primary Structure==== | ====Primary Structure==== | ||
In humans, factor VIII is encoded by the F8 gene <ref name="Ngo" /><ref name="uni">https://www.uniprot.org/uniprot/P00451 [11.01.2019]</ref><ref name="pdb">http://www.rcsb.org/structure/3CDZ [11.01.2019]</ref>. This gene maps on the most distant band of the long arm of the X-chromosome (region Xq28). It is 186 kb in size (0.1 % of the whole size of the chromosome) and contains 26 exons <ref name="Antonarakis" />. | In humans, factor VIII is encoded by the F8 gene <ref name="Ngo" /><ref name="uni">https://www.uniprot.org/uniprot/P00451 [11.01.2019]</ref><ref name="pdb">http://www.rcsb.org/structure/3CDZ [11.01.2019]</ref>. This gene maps on the most distant band of the long arm of the X-chromosome (region Xq28). It is 186 kb in size (0.1 % of the whole size of the chromosome) and contains 26 exons <ref name="Antonarakis" />. | ||
====Secondary Structure==== | ====Secondary Structure==== | ||
