Sandbox Reserved 1482: Difference between revisions
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== History == | == History == | ||
'''1937''': first use of the factor VIII (known | '''1937''': first use of the factor VIII (known as “Antihemophilic Globulin”) to cure blood coagulation disorders thanks to the discovery of F.H.L Patek and A.J Taylor <ref>Patek AJ & Taylor FHL. Hemophilia. II. Some properties of a substance obtained from normal human plasma effective in accelerating the coagulation of hemophilic blood. The Journal of clinical investigation. 1937 Jan; 16(1): 113-124. PMID: 16694450 doi: 10.1172/JCI100829</ref>. | ||
'''1964''': Usual utilisation of concentrated factor VIII to treat hemophilia <ref>Dallman PR & Pool JG. Treatment of hemophilia with factor VIII concentrates. New England Journal of Medicine. 1968 Jan ; 278(4): 199-202. PMID: 5711341 doi: 10.1056/NEJM196801252780406</ref>. | '''1964''': Usual utilisation of concentrated factor VIII to treat hemophilia <ref>Dallman PR & Pool JG. Treatment of hemophilia with factor VIII concentrates. New England Journal of Medicine. 1968 Jan ; 278(4): 199-202. PMID: 5711341 doi: 10.1056/NEJM196801252780406</ref>. | ||
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Factor VIIIa is obtained by cleavage and release of the B domain <ref name="wikipedia" /><ref name="Ngo" /><ref name="toole">Toole JJ, Pittman DD, Orr EC, Murtha P, Wasley LC & Kaufman RJ. A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for ''in vitro'' procoagulant activity. Proceedings of the National Academy of Sciences. 1986 Aug; 83(16): 5939-5942. PMID: 3016730 doi https://doi.org/10.1073/pnas.83.16.5939</ref>. Although factor VIIIa can be formed from at least two cleavages involving Arg372 and Arg1689, fully factor VIIIa is obtained by a third cleavage at Arg740 <ref name="Ngo" />. | Factor VIIIa is obtained by cleavage and release of the B domain <ref name="wikipedia" /><ref name="Ngo" /><ref name="toole">Toole JJ, Pittman DD, Orr EC, Murtha P, Wasley LC & Kaufman RJ. A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for ''in vitro'' procoagulant activity. Proceedings of the National Academy of Sciences. 1986 Aug; 83(16): 5939-5942. PMID: 3016730 doi https://doi.org/10.1073/pnas.83.16.5939</ref>. Although factor VIIIa can be formed from at least two cleavages involving Arg372 and Arg1689, fully factor VIIIa is obtained by a third cleavage at Arg740 <ref name="Ngo" />. | ||
The two chain that result are a heavy and a light chains <ref name="Ngo" /><ref name="El" /><ref name="pdb" />. | The two chain that result are a heavy and a light chains <ref name="Ngo" /><ref name="El" /><ref name="pdb" />. | ||
