Aldolase: Difference between revisions

The regulation of fructose 1,6-bisphosphate aldolase is not well understood, but the understanding is every-increasing.  As it is currently observed, aldolase C appears to be regulated mainly by the gene expression--the concentration of mRNA in the cytoplasm.<ref>Paolella, G, Buono, P, Mancini, F P, Izzo, P, and Salvatore, F. "Structure and expression of mouse aldolase genes." Eur. J. Biochem.. 156. (1986): 229-235.</ref>  It is also known that adenosine 3',5'-cyclicmonophosphate (cAMP) affects the expression of the gene.  cAMP concentration has been positively correlated with aldolase C expression.  It is believed that cAMP acts upon a section of the promotor region, distal element D, causing the transcriptional promoter, NGFI-B, to bind.  Once bound, the promoter activates the transcription of the gene coding for fructose bisphosphate aldolase.<ref>Buono, P, Cassano, S, Alfieri, A, Mancini, A, and Salvatore, F. "Human aldolase C gene expression is regulated by adenosine 30,50-cyclic monophosphate (cAMP) in PC12 cells." Gene. 291. (2002): 115-121.</ref>  Given the inhibitory effects of an oxidant in the presence of aldolase, it is possible that this could be a mechanism of regulation of the enzyme.  The deactivation that accompanies the oxidation of the surface thiol of Cys72 could be used intracellularly to slow the catalysis of the enzyme and regulate glycolysis.<ref name="kinetics" />

[[Aldolase 3D structures]]

</StructureSection>

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}