6cj2: Difference between revisions
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==Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG056== | |||
<StructureSection load='6cj2' size='340' side='right' caption='[[6cj2]], [[Resolution|resolution]] 1.47Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cj2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CJ2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=X27:2-{[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-5-methyl-11-(propan-2-yl)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one'>X27</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cj2 OCA], [http://pdbe.org/6cj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cj2 RCSB], [http://www.ebi.ac.uk/pdbsum/6cj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cj2 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Blacklow, S C]] | |||
[[Category: Xu, X]] | [[Category: Xu, X]] | ||
[[Category: | [[Category: Brd4]] | ||
[[Category: Inhibitor]] | |||
[[Category: Kinase]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription-inhibitor complex]] | |||
Revision as of 07:24, 6 March 2019
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG056
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