6cl2: Difference between revisions
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==Caspase-7 in complex with Ac-ATS009-KE== | |||
<StructureSection load='6cl2' size='340' side='right' caption='[[6cl2]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cl2]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CL2 FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MH:3-PYRIDIN-3-YL-L-ALANINE'>1MH</scene>, <scene name='pdbligand=1U8:(3S)-3-AMINO-5-[(2,6-DIMETHYLBENZOYL)OXY]-4-OXOPENTANOIC+ACID'>1U8</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=PF5:2,3,4,5,6-PENTAFLUORO-L-PHENYLALANINE'>PF5</scene></td></tr> | |||
[[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cl2 OCA], [http://pdbe.org/6cl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cl2 RCSB], [http://www.ebi.ac.uk/pdbsum/6cl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cl2 ProSAT]</span></td></tr> | ||
[[Category: Gonzalez-Paez, G | </table> | ||
[[Category: Solania, A | == Function == | ||
[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caspase-7]] | |||
[[Category: Gonzalez-Paez, G E]] | |||
[[Category: Solania, A T]] | |||
[[Category: Wolan, D W]] | |||
[[Category: Apoptosis]] | |||
[[Category: Hydrolase]] | |||
[[Category: Inhibitor]] | |||
Revision as of 07:26, 6 March 2019
Caspase-7 in complex with Ac-ATS009-KE
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