5ame: Difference between revisions
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==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)== | ==Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)== | ||
<StructureSection load='5ame' size='340' side='right' caption='[[5ame]], [[Resolution|resolution]] 1.58Å' scene=''> | <StructureSection load='5ame' size='340' side='right' caption='[[5ame]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ame]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AME FirstGlance]. <br> | <table><tr><td colspan='2'>[[5ame]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AME FirstGlance]. <br> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref> | [[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref> | ||
==See Also== | |||
*[[Bromodomain-containing protein|Bromodomain-containing protein]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 08:14, 6 March 2019
Crystal structure of the bromodomain of human surface epitope engineered BRD1A in complex with 3D Consortium fragment 4-acetyl- piperazin-2-one (SGC - Diamond I04-1 fragment screening)
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Human
- Arrowsmith, C H
- Bountra, C
- Bowkett, D
- Bradley, A
- Brandao-Neto, J
- Brennan, P
- Burgess-Brown, N
- Collins, P
- Cox, O
- Delft, F von
- Douangamath, A
- Edwards, E
- Fairhead, M
- Krojer, T
- Ng, J T
- Pearce, N M
- Strain-Damerell, C
- Talon, R
- Wright, N
- Bromodomain
- Diamond i04-1
- Epigenetic
- Fragmentscreening
- Histone-binding protein
- Sgc
- Structural genomic
- Transcription
