Anthrax edema factor: Difference between revisions
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== Function == | == Function == | ||
'''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The full anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. The binding of calmodulin to EF changes it from its non-active form to the active one.<ref>PMID:15680766</ref> | '''Anthrax edema factor''' (EF) or '''calmodulin-sensitive adenylate cyclase''' is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The full anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. The binding of calmodulin to EF changes it from its non-active form to the active one.<ref>PMID:15680766</ref> | ||
== Disease == | == Disease == | ||
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*<scene name='48/485623/Cv/2'>EF trimer with 3 calmodulin molecules</scene>. | *<scene name='48/485623/Cv/2'>EF trimer with 3 calmodulin molecules</scene>. | ||
*<scene name='48/485623/Cv/5'>ADP derivative/Yt+3 binding site</scene> of EF. Water molecules are shown as red spheres. | *<scene name='48/485623/Cv/5'>ADP derivative/Yt+3 binding site</scene> of EF. Water molecules are shown as red spheres. | ||
*<scene name='48/485623/Cv/6'>Ca+2 binding site</scene> of calmodulin (PDB code [[1pk0]]).<ref>PMID:14978283</ref> | *<scene name='48/485623/Cv/6'>Ca+2 binding site</scene> of calmodulin (PDB code [[1pk0]]).<ref>PMID:14978283</ref> | ||
==3D structures of anthrax edema factor== | |||
[[Anthrax edema factor 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1k8t]] - EF adenylate cyclase domain<br /> | |||
[[1k93]] - EF adenylate cyclase domain + calmodulin <br /> | |||
[[1k90]] - EF adenylate cyclase domain + calmodulin + deoxy-ATP <br /> | |||
[[1lvc]] – EF adenylate cyclase domain C terminal + calmodulin + anthraniloyl-deoxy-ATP<br /> | [[1lvc]] – EF adenylate cyclase domain C terminal + calmodulin + anthraniloyl-deoxy-ATP<br /> | ||
[[1pk0]] - EF adenylate cyclase domain C terminal + calmodulin + phosphonylmethoxyethyl-ADP<br /> | [[1pk0]] - EF adenylate cyclase domain C terminal + calmodulin + phosphonylmethoxyethyl-ADP<br /> | ||
