6cff: Difference between revisions

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'''Unreleased structure'''


The entry 6cff is ON HOLD  until Mar 28 2020
==Stimulator of Interferon Genes Human==
 
<StructureSection load='6cff' size='340' side='right'caption='[[6cff]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Fernandez, D., Li, L., Ergun, S.L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6cff]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CFF FirstGlance]. <br>
Description: Stimulator of Interferon Genes Human
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cff OCA], [http://pdbe.org/6cff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cff RCSB], [http://www.ebi.ac.uk/pdbsum/6cff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cff ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ergun, S L]]
[[Category: Fernandez, D]]
[[Category: Li, L]]
[[Category: Li, L]]
[[Category: Fernandez, D]]
[[Category: 230g/232r]]
[[Category: Ergun, S.L]]
[[Category: Complex]]
[[Category: Cyclic-di-amp]]
[[Category: Human sting]]
[[Category: Immune system]]
[[Category: Tmem173]]
[[Category: Wild type]]
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