6dya: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6dya is ~~ON HOLD~~ ~~until Paper Publication~~

==WDR5 in complex with a WIN site inhibitor==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6dya]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DYA FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HHM:N-[(3,5-dichlorophenyl)methyl]-3-[(1H-imidazol-1-yl)methyl]benzamide'>HHM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dya OCA], [http://pdbe.org/6dya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dya RCSB], [http://www.ebi.ac.uk/pdbsum/6dya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dya ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Fesik, S W]]

[[Category: Phan, J]]

[[Category: Wang, F]]

[[Category: Epigenetic]]

[[Category: Mll binding]]

[[Category: Transferase-transferase inhibitor complex]]

[[Category: Wd40 repeat]]

[[Category: Win site inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6dya is ON HOLD  until Paper Publication
+==WDR5 in complex with a WIN site inhibitor==
+<StructureSection load='6dya' size='340' side='right'caption='[[6dya]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6dya]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DYA FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HHM:N-[(3,5-dichlorophenyl)methyl]-3-[(1H-imidazol-1-yl)methyl]benzamide'>HHM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dya OCA], [http://pdbe.org/6dya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dya RCSB], [http://www.ebi.ac.uk/pdbsum/6dya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dya ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Fesik, S W]]
+[[Category: Phan, J]]
+[[Category: Wang, F]]
+[[Category: Epigenetic]]
+[[Category: Mll binding]]
+[[Category: Transferase-transferase inhibitor complex]]
+[[Category: Wd40 repeat]]
+[[Category: Win site inhibitor]]