6i07: Difference between revisions
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==Crystal structure of EpCAM in complex with scFv== | |||
<StructureSection load='6i07' size='340' side='right'caption='[[6i07]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6i07]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I07 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | ||
[[Category: Logan, D | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i07 OCA], [http://pdbe.org/6i07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i07 RCSB], [http://www.ebi.ac.uk/pdbsum/6i07 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i07 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] Intestinal epithelial dysplasia;Hereditary nonpolyposis colon cancer. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:18572020</ref> The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.<ref>PMID:19098912</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/EPCAM_HUMAN EPCAM_HUMAN]] May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.<ref>PMID:15195135</ref> <ref>PMID:15922867</ref> <ref>PMID:20064925</ref> <ref>PMID:19785009</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Abu-Yousif, A O]] | |||
[[Category: Boudot, A]] | |||
[[Category: Casaletto, J B]] | |||
[[Category: Chattopadhyay, S]] | |||
[[Category: Fulgham, A]] | |||
[[Category: Geddie, M L]] | |||
[[Category: Hakansson, M]] | |||
[[Category: Harms, B D]] | |||
[[Category: Kalra, A]] | |||
[[Category: Kearns, J D]] | |||
[[Category: Kohli, N]] | |||
[[Category: Logan, D T]] | |||
[[Category: Lugovskoy, A A]] | |||
[[Category: MacBeath, G]] | |||
[[Category: Maiwald, T]] | [[Category: Maiwald, T]] | ||
[[Category: | [[Category: Masson, K]] | ||
[[Category: | [[Category: Nielsen, U B]] | ||
[[Category: Raue, A]] | |||
[[Category: | |||
[[Category: Razlog, M]] | [[Category: Razlog, M]] | ||
[[Category: Schoeberl, B]] | [[Category: Schoeberl, B]] | ||
[[Category: Su, S]] | [[Category: Su, S]] | ||
[[Category: | [[Category: Welin, M]] | ||
[[Category: Epcam]] | |||
[[Category: Immune system]] | |||
[[Category: Scfv]] | |||
[[Category: Single chain fv]] | |||
