6igx: Difference between revisions
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The entry | ==Crystal structure of human CAP-G in complex with CAP-H== | ||
<StructureSection load='6igx' size='340' side='right'caption='[[6igx]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6igx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IGX FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6igx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6igx OCA], [http://pdbe.org/6igx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6igx RCSB], [http://www.ebi.ac.uk/pdbsum/6igx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6igx ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/CND2_HUMAN CND2_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CND3_HUMAN CND3_HUMAN]] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.<ref>PMID:11136719</ref> [[http://www.uniprot.org/uniprot/CND2_HUMAN CND2_HUMAN]] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).<ref>PMID:11136719</ref> <ref>PMID:27737959</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Hara, K]] | |||
[[Category: Hashimoto, H]] | |||
[[Category: Migita, T]] | |||
[[Category: Shimizu, K]] | |||
[[Category: Cell cycle]] | |||
[[Category: Chromosome condensation]] | |||
[[Category: Condensin i subunit]] | |||
[[Category: Heat repeat]] | |||
[[Category: Protein-protein interaction]] | |||
Revision as of 12:04, 13 March 2019
Crystal structure of human CAP-G in complex with CAP-H
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