6imm: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6imm is ~~ON HOLD~~

==Cryo-EM structure of an alphavirus, Sindbis virus==

== Structural highlights ==

<table><tr><td colspan='2'>[[6imm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Sindbis_virus Sindbis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IMM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IMM FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8K6:OCTADECANE'>8K6</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6imm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6imm OCA], [http://pdbe.org/6imm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6imm RCSB], [http://www.ebi.ac.uk/pdbsum/6imm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6imm ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Alphaviruses are enveloped RNA viruses that contain several human pathogens. Due to intrinsic heterogeneity of alphavirus particles, a high resolution structure of the virion is currently lacking. Here we provide a 3.5 A cryo-EM structure of Sindbis virus, using block based reconstruction method that overcomes the heterogeneity problem. Our structural analysis identifies a number of conserved residues that play pivotal roles in the virus life cycle. We identify a hydrophobic pocket in the subdomain D of E2 protein that is stabilized by an unknown pocket factor near the viral membrane. Residues in the pocket are conserved in different alphaviruses. The pocket strengthens the interactions of the E1/E2 heterodimer and may facilitate virus assembly. Our study provides structural insights into alphaviruses that may inform the design of drugs and vaccines.

~~Authors~~:

Implication for alphavirus host-cell entry and assembly indicated by a 3.5A resolution cryo-EM structure.,Chen L, Wang M, Zhu D, Sun Z, Ma J, Wang J, Kong L, Wang S, Liu Z, Wei L, He Y, Wang J, Zhang X Nat Commun. 2018 Dec 14;9(1):5326. doi: 10.1038/s41467-018-07704-x. PMID:30552337<ref>PMID:30552337</ref>

~~Description~~:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased~~ Structures]]

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Sindbis virus]]

[[Category: Chen, L]]

[[Category: Ma, J]]

[[Category: Zhang, X]]

[[Category: Alphavirus]]

[[Category: Glycoprotein]]

[[Category: Virus]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6imm is ON HOLD
+==Cryo-EM structure of an alphavirus, Sindbis virus==
+<StructureSection load='6imm' size='340' side='right'caption='[[6imm]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6imm]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Sindbis_virus Sindbis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IMM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IMM FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8K6:OCTADECANE'>8K6</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6imm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6imm OCA], [http://pdbe.org/6imm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6imm RCSB], [http://www.ebi.ac.uk/pdbsum/6imm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6imm ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Alphaviruses are enveloped RNA viruses that contain several human pathogens. Due to intrinsic heterogeneity of alphavirus particles, a high resolution structure of the virion is currently lacking. Here we provide a 3.5 A cryo-EM structure of Sindbis virus, using block based reconstruction method that overcomes the heterogeneity problem. Our structural analysis identifies a number of conserved residues that play pivotal roles in the virus life cycle. We identify a hydrophobic pocket in the subdomain D of E2 protein that is stabilized by an unknown pocket factor near the viral membrane. Residues in the pocket are conserved in different alphaviruses. The pocket strengthens the interactions of the E1/E2 heterodimer and may facilitate virus assembly. Our study provides structural insights into alphaviruses that may inform the design of drugs and vaccines.
-Authors:
+Implication for alphavirus host-cell entry and assembly indicated by a 3.5A resolution cryo-EM structure.,Chen L, Wang M, Zhu D, Sun Z, Ma J, Wang J, Kong L, Wang S, Liu Z, Wei L, He Y, Wang J, Zhang X Nat Commun. 2018 Dec 14;9(1):5326. doi: 10.1038/s41467-018-07704-x. PMID:30552337<ref>PMID:30552337</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6imm" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Sindbis virus]]
+[[Category: Chen, L]]
+[[Category: Ma, J]]
+[[Category: Zhang, X]]
+[[Category: Alphavirus]]
+[[Category: Glycoprotein]]
+[[Category: Virus]]