6fy4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 6fy4 is ON HOLD until Paper Publication~~

==Structure of human NAD(P) H:quinone oxidoreductase in complex with N-(2-bromophenyl)pyrrolidine-1-sulfonamide==

~~Authors: Gruber, K., Hromic, A.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6fy4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FY4 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FY4 FirstGlance].

~~Description:~~ Structure of human NAD(P) H:quinone oxidoreductase in complex with N-(2-bromophenyl)pyrrolidine-1-sulfonamide

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EAW:N-(2-bromophenyl)pyrrolidine-1-sulfonamide'>EAW</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/NAD(P)H_dehydrogenase_(quinone) NAD(P)H dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.2 1.6.5.2] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fy4 OCA], [http://pdbe.org/6fy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fy4 RCSB], [http://www.ebi.ac.uk/pdbsum/6fy4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fy4 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Gruber, K]]

[[Category: Hromic, A]]

[[Category: ~~Gruber, K~~]]

[[Category: Flavoprotein ligand complex quinone reduction oxidative stress drug metabolism]]

[[Category: Oxidoreductase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6fy4 is ON HOLD  until Paper Publication
+==Structure of human NAD(P) H:quinone oxidoreductase in complex with N-(2-bromophenyl)pyrrolidine-1-sulfonamide==
+<StructureSection load='6fy4' size='340' side='right'caption='[[6fy4]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
-Authors: Gruber, K., Hromic, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6fy4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FY4 FirstGlance]. <br>
-Description: Structure of human NAD(P) H:quinone oxidoreductase in complex with N-(2-bromophenyl)pyrrolidine-1-sulfonamide
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EAW:N-(2-bromophenyl)pyrrolidine-1-sulfonamide'>EAW</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(P)H_dehydrogenase_(quinone) NAD(P)H dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.2 1.6.5.2] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fy4 OCA], [http://pdbe.org/6fy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fy4 RCSB], [http://www.ebi.ac.uk/pdbsum/6fy4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fy4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Gruber, K]]
 [[Category: Hromic, A]]
-[[Category: Gruber, K]]
+[[Category: Flavoprotein ligand complex quinone reduction oxidative stress drug metabolism]]
+[[Category: Oxidoreductase]]