5lou: Difference between revisions
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==human NUDT22== | ==human NUDT22== | ||
<StructureSection load='5lou' size='340' side='right' caption='[[5lou]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='5lou' size='340' side='right'caption='[[5lou]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5lou]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOU FirstGlance]. <br> | <table><tr><td colspan='2'>[[5lou]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOU FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [http://pdbe.org/5lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [http://www.ebi.ac.uk/pdbsum/5lou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [http://pdbe.org/5lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [http://www.ebi.ac.uk/pdbsum/5lou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Human NUDT22 belongs to the diverse NUDIX family of proteins, but has, until now, remained uncharacterized. Here we show that human NUDT22 is a Mg(2+)-dependent UDP-glucose and UDP-galactose hydrolase, producing UMP and glucose 1-phosphate or galactose 1-phosphate. We present the structure of human NUDT22 alone and in a complex with the substrate UDP-glucose. These structures reveal a partially conserved NUDIX fold domain preceded by a unique N-terminal domain responsible for UDP moiety binding and recognition. The NUDIX domain of NUDT22 contains a modified NUDIX box identified using structural analysis and confirmed through functional analysis of mutants. Human NUDT22's distinct structure and function as a UDP-carbohydrate hydrolase establish a unique NUDIX protein subfamily. | |||
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.,Carter M, Jemth AS, Carreras-Puigvert J, Herr P, Martinez Carranza M, Vallin KSA, Throup A, Helleday T, Stenmark P Structure. 2018 Feb 6;26(2):295-303.e6. doi: 10.1016/j.str.2018.01.004. PMID:29413322<ref>PMID:29413322</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5lou" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Carter, M]] | [[Category: Carter, M]] | ||
[[Category: Stenmark, P]] | [[Category: Stenmark, P]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Nudix]] | [[Category: Nudix]] | ||
