4d76: Difference between revisions
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==Human FXIa in complex with small molecule inhibitors.== | ==Human FXIa in complex with small molecule inhibitors.== | ||
<StructureSection load='4d76' size='340' side='right' caption='[[4d76]], [[Resolution|resolution]] 1.77Å' scene=''> | <StructureSection load='4d76' size='340' side='right'caption='[[4d76]], [[Resolution|resolution]] 1.77Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4d76]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D76 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4d76]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D76 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D76 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=J1J:N-[(2S)-1-({5-[(DIAMINOMETHYLIDENE)AMINO]PENTYL}AMINO)-1-OXO-3-PHENYLPROPAN-2-YL]-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-6-CARBOXAMIDE'>J1J</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=J1J:N-[(2S)-1-({5-[(DIAMINOMETHYLIDENE)AMINO]PENTYL}AMINO)-1-OXO-3-PHENYLPROPAN-2-YL]-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-6-CARBOXAMIDE'>J1J</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d7f|4d7f]], [[4d7g|4d7g]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d7f|4d7f]], [[4d7g|4d7g]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d76 OCA], [http://pdbe.org/4d76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d76 RCSB], [http://www.ebi.ac.uk/pdbsum/4d76 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d76 OCA], [http://pdbe.org/4d76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d76 RCSB], [http://www.ebi.ac.uk/pdbsum/4d76 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d76 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. | [[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. | ||
==See Also== | |||
*[[Factor XIa|Factor XIa]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Coagulation factor XIa]] | [[Category: Coagulation factor XIa]] | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Akerud, T]] | [[Category: Akerud, T]] | ||
[[Category: Borjesson, U]] | [[Category: Borjesson, U]] | ||
