6j5v: Difference between revisions

Revision as of 07:04, 3 April 2019

Ligand-triggered allosteric ADP release primes a plant NLR complex

Structural highlights

6j5v is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	BQL, BQO
Activity:	Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[R13L4_ARATH] CC-NB-LRR receptor-like protein required for recognition of the Pseudomonas syringae type III effector HopZ1a. Confers allele-specific recognition and virulence attenuation of HopZ1a. Immunity mediated by ZAR1 is independent of several genes required by other resistance protein signaling pathways such as NDR1 and RAR1.^[1] [PBL2_ARATH] Involved in disease resistance signaling (PubMed:20413097, PubMed:23951354). Contributes to pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling and defense responses downstream of FLS2 (PubMed:20413097). Required for the bacterial XopAC/AvrAC effector-triggered immunity (ETI) against Xanthomonas campestris (PubMed:23951354).^[2] ^[3]

References

↑ Lewis JD, Wu R, Guttman DS, Desveaux D. Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein. PLoS Genet. 2010 Apr 1;6(4):e1000894. doi: 10.1371/journal.pgen.1000894. PMID:20368970 doi:https://dx.doi.org/10.1371/journal.pgen.1000894
↑ Zhang J, Li W, Xiang T, Liu Z, Laluk K, Ding X, Zou Y, Gao M, Zhang X, Chen S, Mengiste T, Zhang Y, Zhou JM. Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host Microbe. 2010 Apr 22;7(4):290-301. doi: 10.1016/j.chom.2010.03.007. PMID:20413097 doi:https://dx.doi.org/10.1016/j.chom.2010.03.007
↑ Guy E, Lautier M, Chabannes M, Roux B, Lauber E, Arlat M, Noel LD. xopAC-triggered immunity against Xanthomonas depends on Arabidopsis receptor-like cytoplasmic kinase genes PBL2 and RIPK. PLoS One. 2013 Aug 9;8(8):e73469. doi: 10.1371/journal.pone.0073469. eCollection , 2013. PMID:23951354 doi:https://dx.doi.org/10.1371/journal.pone.0073469

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OCA

[1] Lewis JD, Wu R, Guttman DS, Desveaux D. Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein. PLoS Genet. 2010 Apr 1;6(4):e1000894. doi: 10.1371/journal.pgen.1000894. PMID:20368970 doi:https://dx.doi.org/10.1371/journal.pgen.1000894

[2] Zhang J, Li W, Xiang T, Liu Z, Laluk K, Ding X, Zou Y, Gao M, Zhang X, Chen S, Mengiste T, Zhang Y, Zhou JM. Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host Microbe. 2010 Apr 22;7(4):290-301. doi: 10.1016/j.chom.2010.03.007. PMID:20413097 doi:https://dx.doi.org/10.1016/j.chom.2010.03.007

[3] Guy E, Lautier M, Chabannes M, Roux B, Lauber E, Arlat M, Noel LD. xopAC-triggered immunity against Xanthomonas depends on Arabidopsis receptor-like cytoplasmic kinase genes PBL2 and RIPK. PLoS One. 2013 Aug 9;8(8):e73469. doi: 10.1371/journal.pone.0073469. eCollection , 2013. PMID:23951354 doi:https://dx.doi.org/10.1371/journal.pone.0073469

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6j5v is ON HOLD  until Paper Publication
+==Ligand-triggered allosteric ADP release primes a plant NLR complex==
+<StructureSection load='6j5v' size='340' side='right'caption='[[6j5v]], [[Resolution|resolution]] 4.25&Aring;' scene=''>
-Authors: Jizong, W., jia, W., Meijuan, H., Hongwei, W., Jianmin, Z., Jijie, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6j5v]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J5V FirstGlance]. <br>
-Description: Ligand-triggered allosteric ADP release primes a plant NLR complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BQL:[(2~{S})-2-azanyl-3-oxidanylidene-propyl]+[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>BQL</scene>, <scene name='pdbligand=BQO:[(2~{R},3~{S})-3-azanyl-4-oxidanylidene-butan-2-yl]+[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>BQO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j5v OCA], [http://pdbe.org/6j5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j5v RCSB], [http://www.ebi.ac.uk/pdbsum/6j5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j5v ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/R13L4_ARATH R13L4_ARATH]] CC-NB-LRR receptor-like protein required for recognition of the Pseudomonas syringae type III effector HopZ1a. Confers allele-specific recognition and virulence attenuation of HopZ1a. Immunity mediated by ZAR1 is independent of several genes required by other resistance protein signaling pathways such as NDR1 and RAR1.<ref>PMID:20368970</ref>  [[http://www.uniprot.org/uniprot/PBL2_ARATH PBL2_ARATH]] Involved in disease resistance signaling (PubMed:20413097, PubMed:23951354). Contributes to pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling and defense responses downstream of FLS2 (PubMed:20413097). Required for the bacterial XopAC/AvrAC effector-triggered immunity (ETI) against Xanthomonas campestris (PubMed:23951354).<ref>PMID:20413097</ref> <ref>PMID:23951354</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Hongwei, W]]
+[[Category: Jianmin, Z]]
 [[Category: Jijie, C]]
-[[Category: Jianmin, Z]]
+[[Category: Jizong, W]]
 [[Category: Meijuan, H]]
-[[Category: Jizong, W]]
 [[Category: Jia, W]]
-[[Category: Hongwei, W]]
+[[Category: Pbl2-ump]]
+[[Category: Plant protein]]
+[[Category: Rks1]]
+[[Category: Zar1]]

6j5v: Difference between revisions

Revision as of 07:04, 3 April 2019

Ligand-triggered allosteric ADP release primes a plant NLR complex

Structural highlights

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