6mjm: Difference between revisions
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==Substrate Free Cytochrome P450 3A5 (CYP3A5)== | |||
<StructureSection load='6mjm' size='340' side='right'caption='[[6mjm]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mjm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5veu|5veu]]</td></tr> | ||
[[Category: Johnson, E | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjm OCA], [http://pdbe.org/6mjm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjm RCSB], [http://www.ebi.ac.uk/pdbsum/6mjm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjm ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/CP3A5_HUMAN CP3A5_HUMAN]] Tacrolimus dose selection. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CP3A5_HUMAN CP3A5_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Unspecific monooxygenase]] | |||
[[Category: Hsu, M H]] | |||
[[Category: Johnson, E F]] | |||
[[Category: Cytochrome p450]] | |||
[[Category: Drug metabolism]] | |||
[[Category: Membrane protein]] | |||
[[Category: Monooxygenase]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 07:07, 3 April 2019
Substrate Free Cytochrome P450 3A5 (CYP3A5)
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