6nfj: Difference between revisions
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==Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide== | |||
<StructureSection load='6nfj' size='340' side='right'caption='[[6nfj]], [[Resolution|resolution]] 3.19Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nfj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NFJ FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfj OCA], [http://pdbe.org/6nfj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nfj RCSB], [http://www.ebi.ac.uk/pdbsum/6nfj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfj ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/KLOTB_HUMAN KLOTB_HUMAN]] Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). [[http://www.uniprot.org/uniprot/FGF19_HUMAN FGF19_HUMAN]] Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.<ref>PMID:12815072</ref> <ref>PMID:16597617</ref> <ref>PMID:17623664</ref> <ref>PMID:19085950</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Kuzina, E]] | |||
[[Category: Lee, S]] | |||
[[Category: Schlessinger, J]] | |||
[[Category: Fgf19]] | |||
[[Category: Klotho]] | |||
[[Category: Nanobody]] | |||
[[Category: Receptor tyrosine kinase]] | |||
[[Category: Signaling]] | |||
[[Category: Signaling protein]] | |||
Revision as of 07:09, 3 April 2019
Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide
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