5l3a: Difference between revisions
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==Fragment-based discovery of 6-arylindazole JAK inhibitors== | ==Fragment-based discovery of 6-arylindazole JAK inhibitors== | ||
<StructureSection load='5l3a' size='340' side='right' caption='[[5l3a]], [[Resolution|resolution]] 1.98Å' scene=''> | <StructureSection load='5l3a' size='340' side='right'caption='[[5l3a]], [[Resolution|resolution]] 1.98Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5l3a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L3A FirstGlance]. <br> | <table><tr><td colspan='2'>[[5l3a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L3A FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6DP:~{N}-(1~{H}-INDAZOL-4-YL)METHANESULFONAMIDE'>6DP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6DP:~{N}-(1~{H}-INDAZOL-4-YL)METHANESULFONAMIDE'>6DP</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JAK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l3a OCA], [http://pdbe.org/5l3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l3a RCSB], [http://www.ebi.ac.uk/pdbsum/5l3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l3a ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l3a OCA], [http://pdbe.org/5l3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l3a RCSB], [http://www.ebi.ac.uk/pdbsum/5l3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l3a ProSAT]</span></td></tr> | ||
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</div> | </div> | ||
<div class="pdbe-citations 5l3a" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5l3a" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Janus kinase|Janus kinase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
[[Category: Dack, K N]] | [[Category: Dack, K N]] | ||
