Paclitaxel: Difference between revisions

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Association Kinetic Constant (K+1) = 3.63x10<sup>6</sup> M<sup>-1</sup>S<sup>-1</sup>
Association Kinetic Constant (K+1) = 3.63x10<sup>6</sup> M<sup>-1</sup>S<sup>-1</sup>
Dissociation Kinetic Constant (K-1) = 9.10x10<sup>-2</sup> M<sup>-1</sup>s<sup>-1</sup>
Dissociation Kinetic Constant (K-1) = 9.10x10<sup>-2</sup> M<sup>-1</sup>s<sup>-1</sup>
Refer to Table 1 to view the kinetic constants of Paclitaxel association and dissociation from cross-linked microtubules at different temperatures (25°C-40°C).
The free energy of the binding of Paclitaxel at 37°C is around -45kJ/mol. The binding reaction is endothermic, which explains why Paclitaxel induces microtubule assembly at low temperatures. <ref name="jose" />
The free energy of the binding of Paclitaxel at 37°C is around -45kJ/mol. The binding reaction is endothermic, which explains why Paclitaxel induces microtubule assembly at low temperatures. <ref name="jose" />


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