6bdn: Difference between revisions
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==Crystal structure of human TAO3 kinase binding ADP== | |||
<StructureSection load='6bdn' size='340' side='right'caption='[[6bdn]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bdn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BDN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdn OCA], [http://pdbe.org/6bdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bdn RCSB], [http://www.ebi.ac.uk/pdbsum/6bdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TAOK3_HUMAN TAOK3_HUMAN]] Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).<ref>PMID:10559204</ref> <ref>PMID:10924369</ref> <ref>PMID:17396146</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Non-specific serine/threonine protein kinase]] | |||
[[Category: Aleshin, A E]] | |||
[[Category: Bankton, L A]] | |||
[[Category: Courtneidge, S A]] | |||
[[Category: Liddington, R C]] | |||
[[Category: Pinkerton, A]] | |||
[[Category: Adt-binding]] | |||
[[Category: Kinase]] | |||
[[Category: Mapk cascade]] | |||
[[Category: Serine/threonine-protein kinase]] | |||
[[Category: Taok3]] | |||
[[Category: Transferase]] | |||
Revision as of 07:07, 10 April 2019
Crystal structure of human TAO3 kinase binding ADP
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