6d07: Difference between revisions
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==Crystal structure of the complex between human chromobox homolog 1 (CBX1) and H3K9me3 peptide== | |||
<StructureSection load='6d07' size='340' side='right'caption='[[6d07]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6d07]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D07 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6d08|6d08]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d07 OCA], [http://pdbe.org/6d07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d07 RCSB], [http://www.ebi.ac.uk/pdbsum/6d07 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d07 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CBX1_HUMAN CBX1_HUMAN]] Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Arora, S]] | |||
[[Category: Horne, W S]] | |||
[[Category: Islam, K]] | |||
[[Category: Bump-hole]] | |||
[[Category: Chromodomain]] | |||
[[Category: Epigenetic]] | |||
[[Category: Lysine modification]] | |||
[[Category: Protein binding]] | |||
Revision as of 07:10, 10 April 2019
Crystal structure of the complex between human chromobox homolog 1 (CBX1) and H3K9me3 peptide
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