6g6u: Difference between revisions
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The | ==The dynamic nature of the VDAC1 channels in bilayers: human VDAC1 at 2.7 Angstrom resolution== | ||
<StructureSection load='6g6u' size='340' side='right'caption='[[6g6u]], [[Resolution|resolution]] 2.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6g6u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G6U FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g6u OCA], [http://pdbe.org/6g6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g6u RCSB], [http://www.ebi.ac.uk/pdbsum/6g6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g6u ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/VDAC1_HUMAN VDAC1_HUMAN]] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:11845315</ref> <ref>PMID:15033708</ref> <ref>PMID:18755977</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Gribbon, P]] | [[Category: Gribbon, P]] | ||
[[Category: Loew, C]] | |||
[[Category: Razeto, A]] | [[Category: Razeto, A]] | ||
[[Category: | [[Category: Apoptosis]] | ||
[[Category: B-barrel]] | |||
[[Category: Cytochrome c release]] | |||
[[Category: Ion-channel]] | |||
[[Category: Outer mitochondrial membrane]] | |||
[[Category: Transport protein]] | |||
Revision as of 07:18, 10 April 2019
The dynamic nature of the VDAC1 channels in bilayers: human VDAC1 at 2.7 Angstrom resolution
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