Uncoupling Protein 2: Difference between revisions
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== History == | == History == | ||
In 1963, researchers discovered that mitochondria have their own DNA or "blueprint" (mtDNA), which is different than the nuclear DNA (nDNA) found in the cells' nucleus. <ref>Mitochondrial Disorder Medical Information. http://www.mitoaction.org/medical-information.</ref> Later, in 1988, mutations of this mitochondria DNA was discovered. Mutations like deletions and point mutations were found in all the mitochondrial disorders.<ref>Luft, R.; Luthman, H. Physiopathology of mitochondria. From Luft's disease to aging and diabetes. https://www.ncbi.nlm.nih.gov/pubmed/8366714.</ref> | In 1963, researchers discovered that mitochondria have their own DNA or "blueprint" (mtDNA), which is different than the nuclear DNA (nDNA) found in the cells' nucleus. <ref>Mitochondrial Disorder Medical Information. http://www.mitoaction.org/medical-information.</ref> Later, in 1988, mutations of this mitochondria DNA was discovered. Mutations like deletions and point mutations were found in all the mitochondrial disorders.<ref>Luft, R.; Luthman, H. Physiopathology of mitochondria. From Luft's disease to aging and diabetes. https://www.ncbi.nlm.nih.gov/pubmed/8366714.</ref> The discovery of five UCPs are of great importance to the study of the mitochondria. A sequence relating to UCP1 lead to the ultimate discovery of UCP2 in 1997. <ref>Sreedhar, A.; Zhao, Y. Uncoupling protein 2 and metabolic diseases. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477468/</ref> | ||
== Disease == | == Disease == | ||
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Figure 2: Uncoupling Protein 2 | Figure 2: Uncoupling Protein 2 | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
