6qjf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 6qjf is ON HOLD until Paper Publication~~

==Crystal Structure of the third PDZ domain of PSD-95 protein D332P mutant: space group C121, structure 1==

~~Authors: Camara-Artigas, A.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6qjf]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5oi4 5oi4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJF FirstGlance]. <br>

~~Description:~~ Crystal Structure of the third PDZ domain of PSD-95 protein D332P mutant: space group C121, structure 1

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5oi4|5oi4]]</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qjf OCA], [http://pdbe.org/6qjf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qjf RCSB], [http://www.ebi.ac.uk/pdbsum/6qjf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qjf ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Camara-Artigas, A]]

[[Category: Pdz domain]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6qjf is ON HOLD  until Paper Publication
+==Crystal Structure of the third PDZ domain of PSD-95 protein D332P mutant: space group C121, structure 1==
+<StructureSection load='6qjf' size='340' side='right'caption='[[6qjf]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Camara-Artigas, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6qjf]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5oi4 5oi4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJF FirstGlance]. <br>
-Description: Crystal Structure of the third PDZ domain of PSD-95 protein D332P mutant: space group C121, structure 1
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5oi4|5oi4]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qjf OCA], [http://pdbe.org/6qjf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qjf RCSB], [http://www.ebi.ac.uk/pdbsum/6qjf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qjf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Camara-Artigas, A]]
+[[Category: Pdz domain]]
+[[Category: Signaling protein]]