6cxw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6cxw is ~~ON HOLD until Paper Publication~~

==Synaptotagmin 1 C2A beta4 chimera with enhanced PIP2 binding function==

~~Authors~~: ~~Sutton~~, R.B.

== Structural highlights ==

<table><tr><td colspan='2'>[[6cxw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CXW FirstGlance]. <br>

~~Description~~: ~~Synaptotagmin 1 C2A beta4 chimera~~ with ~~enhanced PIP2 binding function~~

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wee|4wee]]</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cxw OCA], [http://pdbe.org/6cxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cxw RCSB], [http://www.ebi.ac.uk/pdbsum/6cxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cxw ProSAT]</span></td></tr>

[[Category: Sutton, R.B]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Sutton, R B]]

[[Category: C2 domain]]

[[Category: Exocytosis]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6cxw is ON HOLD  until Paper Publication
+==Synaptotagmin 1 C2A beta4 chimera with enhanced PIP2 binding function==
+<StructureSection load='6cxw' size='340' side='right'caption='[[6cxw]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
-Authors: Sutton, R.B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6cxw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CXW FirstGlance]. <br>
-Description: Synaptotagmin 1 C2A beta4 chimera with enhanced PIP2 binding function
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wee|4wee]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cxw OCA], [http://pdbe.org/6cxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cxw RCSB], [http://www.ebi.ac.uk/pdbsum/6cxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cxw ProSAT]</span></td></tr>
-[[Category: Sutton, R.B]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Sutton, R B]]
+[[Category: C2 domain]]
+[[Category: Exocytosis]]