6cyj: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6cyj is ~~ON HOLD until Paper Publication~~

==Mycobacterium tuberculosis transcriptional regulator==

~~Authors~~: ~~Tang~~, S., ~~Sacchettini~~, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[6cyj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYJ OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CYJ FirstGlance].

~~Description~~: ~~Mycobacterium tuberculosis~~ transcriptional ~~regulator~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SCA:SUCCINYL-COENZYME+A'>SCA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[6cz6|6cz6]], [[6cyy|6cyy]], [[6d2s|6d2s]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyj OCA], [http://pdbe.org/6cyj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cyj RCSB], [http://www.ebi.ac.uk/pdbsum/6cyj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyj ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PRPR_MYCTU PRPR_MYCTU]] Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route) (PubMed:22916289, PubMed:24705740). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate (PubMed:22365605). PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor (PubMed:22916289). During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA, which encodes the DnaA initiator protein responsible for initiating chromosomal replication (PubMed:24705740). It is possibly involved in the regulation of genes responsible for controlling cholesterol utilization (PubMed:22365605).<ref>PMID:22365605</ref> <ref>PMID:22916289</ref> <ref>PMID:24705740</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Sacchettini, J]]

[[Category: Tang, S]]

[[Category: ~~Sacchettini, J~~]]

[[Category: Dna binding protein]]

[[Category: Transcription]]

[[Category: Transcriptional regulator]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6cyj is ON HOLD  until Paper Publication
+==Mycobacterium tuberculosis transcriptional regulator==
+<StructureSection load='6cyj' size='340' side='right'caption='[[6cyj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors: Tang, S., Sacchettini, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6cyj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CYJ FirstGlance]. <br>
-Description: Mycobacterium tuberculosis transcriptional regulator
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCA:SUCCINYL-COENZYME+A'>SCA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6cz6|6cz6]], [[6cyy|6cyy]], [[6d2s|6d2s]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyj OCA], [http://pdbe.org/6cyj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cyj RCSB], [http://www.ebi.ac.uk/pdbsum/6cyj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyj ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PRPR_MYCTU PRPR_MYCTU]] Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route) (PubMed:22916289, PubMed:24705740). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate (PubMed:22365605). PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor (PubMed:22916289). During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA, which encodes the DnaA initiator protein responsible for initiating chromosomal replication (PubMed:24705740). It is possibly involved in the regulation of genes responsible for controlling cholesterol utilization (PubMed:22365605).<ref>PMID:22365605</ref> <ref>PMID:22916289</ref> <ref>PMID:24705740</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Sacchettini, J]]
 [[Category: Tang, S]]
-[[Category: Sacchettini, J]]
+[[Category: Dna binding protein]]
+[[Category: Transcription]]
+[[Category: Transcriptional regulator]]