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==Triazolopyridine compounds as selective JAK1 inhibitors: from hit identification to GLPG0634==
==Triazolopyridine compounds as selective JAK1 inhibitors: from hit identification to GLPG0634==
<StructureSection load='4p7e' size='340' side='right' caption='[[4p7e]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4p7e' size='340' side='right'caption='[[4p7e]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4p7e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P7E FirstGlance]. <br>
<table><tr><td colspan='2'>[[4p7e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P7E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HB:N-(5-{4-[(1,1-DIOXIDOTHIOMORPHOLIN-4-YL)METHYL]PHENYL}[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-2-YL)CYCLOPROPANECARBOXAMIDE'>2HB</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HB:N-(5-{4-[(1,1-DIOXIDOTHIOMORPHOLIN-4-YL)METHYL]PHENYL}[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-2-YL)CYCLOPROPANECARBOXAMIDE'>2HB</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JAK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7e OCA], [http://pdbe.org/4p7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p7e RCSB], [http://www.ebi.ac.uk/pdbsum/4p7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p7e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7e OCA], [http://pdbe.org/4p7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p7e RCSB], [http://www.ebi.ac.uk/pdbsum/4p7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p7e ProSAT]</span></td></tr>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Aar, E M.van der]]
[[Category: Aar, E M.van der]]
Retrieved from "https://proteopedia.org/4p7e"