4pmt: Difference between revisions
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==The structure of TrkA kinase bound to the inhibitor N~4~-(4-morpholin-4-ylphenyl)-N~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine== | ==The structure of TrkA kinase bound to the inhibitor N~4~-(4-morpholin-4-ylphenyl)-N~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine== | ||
<StructureSection load='4pmt' size='340' side='right' caption='[[4pmt]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='4pmt' size='340' side='right'caption='[[4pmt]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4pmt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PMT FirstGlance]. <br> | <table><tr><td colspan='2'>[[4pmt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PMT FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31Y:N~4~-[4-(MORPHOLIN-4-YL)PHENYL]-N~6~-(PYRIDIN-3-YLMETHYL)PYRIDO[3,2-D]PYRIMIDINE-4,6-DIAMINE'>31Y</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31Y:N~4~-[4-(MORPHOLIN-4-YL)PHENYL]-N~6~-(PYRIDIN-3-YLMETHYL)PYRIDO[3,2-D]PYRIMIDINE-4,6-DIAMINE'>31Y</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pmm|4pmm]], [[4pmp|4pmp]], [[4pms|4pms]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pmm|4pmm]], [[4pmp|4pmp]], [[4pms|4pms]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NTRK1, MTC, TRK, TRKA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pmt OCA], [http://pdbe.org/4pmt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pmt RCSB], [http://www.ebi.ac.uk/pdbsum/4pmt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pmt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pmt OCA], [http://pdbe.org/4pmt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pmt RCSB], [http://www.ebi.ac.uk/pdbsum/4pmt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pmt ProSAT]</span></td></tr> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4pmt" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4pmt" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[High affinity nerve growth factor receptor|High affinity nerve growth factor receptor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
[[Category: Su, H P]] | [[Category: Su, H P]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
