5zrn: Difference between revisions
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==Inhibitor bound crystal structure of N-terminal domain of FACL13 from Mycobacterium tuberculosis== | |||
<StructureSection load='5zrn' size='340' side='right'caption='[[5zrn]], [[Resolution|resolution]] 2.37Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5zrn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZRN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZRN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JSA:5-O-{[(1R)-1-hydroxydodecyl]sulfamoyl}adenosine'>JSA</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t5b|3t5b]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Long-chain-fatty-acid--CoA_ligase Long-chain-fatty-acid--CoA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.2.1.3 6.2.1.3] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zrn OCA], [http://pdbe.org/5zrn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zrn RCSB], [http://www.ebi.ac.uk/pdbsum/5zrn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zrn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/FAC13_MYCTO FAC13_MYCTO]] Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Long-chain-fatty-acid--CoA ligase]] | |||
[[Category: Goyal, A]] | |||
[[Category: Sankaranarayanan, R]] | [[Category: Sankaranarayanan, R]] | ||
[[Category: | [[Category: Facl13]] | ||
[[Category: Fatty acyl coa ligase]] | |||
[[Category: Inhibitor]] | |||
[[Category: Ligase]] | |||
[[Category: Lipid metabolism]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
Revision as of 06:35, 24 April 2019
Inhibitor bound crystal structure of N-terminal domain of FACL13 from Mycobacterium tuberculosis
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