6dzy: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6dzy is ~~ON HOLD~~

==Cryo-EM structure of the ts2-active human serotonin transporter in complex with 15B8 Fab and 8B6 ScFv bound to ibogaine==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6dzy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZY OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZY FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=HJM:(5beta)-12-methoxyibogamine'>HJM</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzy OCA], [http://pdbe.org/6dzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dzy RCSB], [http://www.ebi.ac.uk/pdbsum/6dzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzy ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SC6A4_HUMAN SC6A4_HUMAN]] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.<ref>PMID:17506858</ref> <ref>PMID:18227069</ref> <ref>PMID:19270731</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Coleman, J A]]

[[Category: Gouaux, E]]

[[Category: Yang, D]]

[[Category: Fab]]

[[Category: Human serotonin transporter]]

[[Category: Ibogaine]]

[[Category: Transport protein-immune system complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6dzy is ON HOLD
+==Cryo-EM structure of the ts2-active human serotonin transporter in complex with 15B8 Fab and 8B6 ScFv bound to ibogaine==
+<StructureSection load='6dzy' size='340' side='right'caption='[[6dzy]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6dzy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DZY FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HJM:(5beta)-12-methoxyibogamine'>HJM</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dzy OCA], [http://pdbe.org/6dzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dzy RCSB], [http://www.ebi.ac.uk/pdbsum/6dzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dzy ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SC6A4_HUMAN SC6A4_HUMAN]] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.<ref>PMID:17506858</ref> <ref>PMID:18227069</ref> <ref>PMID:19270731</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Coleman, J A]]
+[[Category: Gouaux, E]]
+[[Category: Yang, D]]
+[[Category: Fab]]
+[[Category: Human serotonin transporter]]
+[[Category: Ibogaine]]
+[[Category: Transport protein-immune system complex]]